Simba, who have two games in hand, are breathing heavily down on their necks, just six points adrift of their rivals.
Yanga last hosted a league match on December 6 last year against Ruvu Shooting and it ended in a 2-1 victory.
It will match number 20 for Yanga, who won the reverse fixture courtesy of a solitary goal by Congolese anchorman Mukoko Tonombe at Kaitaba Stadium in Kagera.
When they are done with the Kagera assignment, the Tanzania Mainland Premier League leaders host Mtibwa Sugar at the same venue on Saturday for yet another tough duel.
They currently sit at the apex of the table after amassing 45 points from 19 matches. On Wednesday afternoon, they have an opportunity to stretch their lead to nine points, which would pile pressure on their bitter rivals Simba.
Burundian coach Cedric Kaze will be hoping his charges bounce back to winning ways after being held to a 1-1 draw by Mbeya City in their previous encounter at Sokoine Memorial Stadium in Mbeya last Saturday.
The draw was Yanga’s sixth of the season as they continue enjoying an unbeaten run after 19 league matches this season.
Kaze will, however, be a worried man after his charges only managed 30 goals in 19 encounters, although they have been decent at the back, only letting in eight goals.
He will be aware that Kagera Sugar always gives Yanga problems whenever the two meet. Kagera has everything to play for as a win could move them from position ten to seven.
Under the tutelage of Mecky Mexime, they narrowly missed relegation last season and need to fight hard early to stay above the waters.
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